2026年9月24日

Author Correction: Large recoverable elastic energy in chiral metamaterials via twist buckling

Peter Gumbsch

Chiral oxazolidinones via biocatalytic aziridination of unactivated alkenes

Frances H. Arnold

Bank accounts reveal the fingerprints of abusive financial control

Nick Petrić Howe

Competition heats up in the regenerative-medicine ranks

Huge hoard of metal bars hints at vast Iron Age trade

The gene-regulatory evolution of the human skeleton

David Gokhman

Abstract Skeletal modifications were central to human evolution, enabling adaptations for bipedalism, large cranial vaults and childbirth 1 . Despite their importance, the genetic changes that gave rise to the unique human form remain mostly unknown 2 . Here we systematically map the gene-regulatory changes that shaped human skeletal evolution. Using massively parallel reporter assays (MPRAs) in chondrocytes, we assayed 561,410 human-derived substitutions in promoters and enhancers, identifying 15,077 loci with human-specific regulatory activity. We then generated human–ape hybrid cells and differentiated them into osteochondral progenitors. Integrating the hybrid cells with MPRA measurements produced genome-wide atlases of human-specific changes in cis -regulatory expression, and the seq…

The anthropogenic fingerprint on emerging infectious diseases

Colin J. Carlson

Abstract Emerging infectious diseases are a hallmark of the Anthropocene 1,2 . Human-driven ecosystem changes and human–wildlife–livestock contact can drive the emergence of zoonotic and vector-borne diseases 3–5 , but how much these processes shape landscapes of outbreak risk is poorly understood, beyond a few well-studied systems 6–8 . Here we consolidate 58,319 outbreak event records for 32 diseases and systematically test how 16 hypothesized social and environmental drivers impact outbreak geographies, while accounting for detection and reporting biases. We show that outbreak risks are typically highest in mosaic landscapes where people and livestock live alongside forests and fragmented ecosystems. These combined factors, along with long-term declines in precipitation, share strong i…

Gravitational torque drives multidecadal variations in length of day

Mathieu Dumberry

Single-nucleus transcriptome-wide association study of human brain disorders

Panos Roussos

Abstract Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging 1 . Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many of these loci lie in non-coding regions that influence gene expression in specific cell types 2–5 . Traditional bulk brain transcriptomic analyses, which often focus on European ancestry cohorts, average over cellular diversity, obscuring genetic risk-related changes in gene expression. Here we use single-nucleus gene expression profiles from the dorsolateral prefrontal cortex in the multi-ancestry PsychAD cohort to develop transcriptomic imputation models of genetically regulated expression across major brain ce…

Lu+ optical frequency references with accuracy verified at the 19th digit

M. D. Barrett

Sequence-encoded hexagonal lattices in multichannel peptide nanofibrils

Tanja Weil

Abstract Structural complexity in biological matter arises from molecular information that encodes supramolecular assembly across length scales 1–3 . Here we show that minimal nine-residue peptides can encode discrete lateral interaction motifs that direct supramolecular organization. These motifs generate hexagonal pores and hierarchically tile into multichannel nanofibrils with defined topology. Sequence-encoded amphiphilicity combines a cross-β-dimer, an inversion point and a trimeric junction to create complementary interfaces that couple lateral growth to axial stacking, yielding honeycomb lattices with continuous approximately 5-nm solvent-accessible nanochannels. Cryo-electron microscopy resolves the supramolecular architecture and shows that lattice symmetry and pore geometry are…

Banking records reveal characteristics of financial abuse

David Leake

Abstract The experience of financial abuse, a form of domestic abuse involving control over money and finances, can be severe and long-lasting 1–3 , yet difficult to document 4 . Evidence on the everyday experiences of victim-survivors in the context of financial abuse is drawn primarily from small-scale, qualitative surveys 5,6 . Using anonymized banking data from a major UK retail bank, we compared the financial outcomes of a group of female victim-survivors of financial abuse ( n = 5,428; identified from customer disclosures to the bank) with a control group ( n = 15,602; consisting of individuals with no known disclosures). The control group matched the demographic and socioeconomic characteristics of the victim-survivor group 7 years before disclosure. A comprehensive set of 373 tran…

Hepatocytes promote liver metastasis of pancreatic cancer by providing serine

Alec C. Kimmelman

A design approach for bitopic kinase inhibitors

Kevan M. Shokat

Abstract Traditional kinase inhibitors face a trade-off between potency and selectivity because their affinity depends on limited molecular interactions in a single highly conserved binding site. Bitopic inhibitors overcome this limitation by engaging multiple sites on the same target 1 . Here, using ABL1 and EGFR as model kinases, we systematically explore the bitopic-specific design parameters of ligand choice, linkage vector and linker length and show that they affect potency through inter-ligand cooperativity and linker entropy. We apply this approach to address an unmet clinical need: existing inhibitors of ABL1, an important target in BCR :: ABL1 -driven leukaemias, are constrained by resistance mutations and off-target effects 2 . The third-generation inhibitor ponatinib overcomes…

A methanogen hydrolase reveals the structure of archaeal peptidoglycan

Simonetta Gribaldo

Earlier and faster heatwave onset on land under a warming climate

Juxiu Liu

Sudden collapse of submarine volcano drives extreme hazards

Reduced Asian monsoon influence on Mediterranean summers in a warmer climate

Zhun Guo

Global carbon dioxide flux into the surface ocean intensified by rain-induced dilution

Wade R. McGillis

Divergent deep-sea temperatures in the Pacific and Atlantic during the onset of Antarctic glaciation

A. Nele Meckler

Far-right political support and clean technology adoption in Germany

Dirk Neumann

Abstract The diffusion of clean technologies is critical for climate goals, yet political polarization influences adoption. Here we examine how ideology affects residential solar photovoltaic (PV) and electric vehicle (EV) uptake in Germany, drawing on responses from a three-wave individual-level survey, municipality-level observations of PV and EV registrations and election results. Supporters of the far-right Alternative für Deutschland (AfD) show significantly lower willingness to adopt EVs and, to a lesser degree, PV systems compared with supporters of the pro-environmental Bündnis 90 / Die Grünen (GRÜNE) party. However, polarization is not static. The relative adoption gap between municipalities with strong AfD support and those with strong GRÜNE support declined from 76% to 31% for…